HCID 15491191, compound → HCID 15491198, compound

HRID 1954692Notes

Reaction equation

HRID 1954692 reaction equation
O[C:2]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:3][CH2:4][C:5]([C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:6]>CO.[Pd]>[CH3:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)([C:14]1[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=1)[CH2:4][CH2:3][CH:2]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 1

HCID 15491191HCID 15491191, compound

Product 1

HCID 15491198HCID 15491198, compoundYield 85.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of the product from Example 1 (2.00 g, 4.71 mmol) in 100 mL of methanol was shaken with 20% Pd/C (0.25 g) on a Parr apparatus under a H2 atmosphere (50 psi) for 21 hours. The reaction mixture was filtered and the filtrate concentrated to give the title compound (1.64 g, 85%) as a white foam.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-0dbd8ad7b82842c6a8b86aa3f0de940c
Source dataset
uspto-grants-2000_09
Patent number
US06124280

Reaction notes

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