Oxalic Acid → HCID 70072439, compound

HRID 1954697Notes

Reaction equation

HRID 1954697 reaction equation
[N:1]1([CH2:8][C:9]2[CH:10]=[C:11]([CH:16]([C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][N:35]4[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]4)[CH:28]=3)[CH2:17][NH:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:12]=[CH:13][C:14]=2[OH:15])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:42]([OH:47])(=[O:46])[C:43]([OH:45])=[O:44].C(OCC)(=O)C>C(O)C>[C:42]([OH:47])(=[O:46])[C:43]([OH:45])=[O:44].[N:1]1([CH2:8][C:9]2[CH:10]=[C:11]([CH:16]([C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([CH2:34][N:35]4[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]4)[CH:28]=3)[CH2:17][NH:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:12]=[CH:13][C:14]=2[OH:15])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 971Oxalic AcidHCID 8857Ethyl AcetateHCID 44460793HCID 44460793, compound

Product 1

HCID 70072439HCID 70072439, compoundYield 75.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the product from Example 16 (0.94 g, 1.79 mmol) and oxalic acid (0.26 g, 2.00 mmol) in 5 mL ethanol was triturated with ethyl acetate. The solid which formed was collected by filtration and dried under vacuum at 75° C. to give the title compound (0.875 g, 66%) as a white solid.

Workup

  1. customThe solid which formed
  2. filtrationwas collected by filtration
  3. customdried under vacuum at 75° C.

Sources & evidence

ORD record
ord-5b892812cb6c4e3c8465d1f79f7eb521
Source dataset
uspto-grants-2000_09
Patent number
US06124280

Reaction notes

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