Piperidine → HCID 4625284, compound

HRID 1954712Notes

Reaction equation

HRID 1954712 reaction equation
Cl[C:2]1[C:3]2[N:4]([CH:12]=[CH:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[C:3]3[N:4]([CH:12]=[CH:13][N:14]=3)[C:5]3[C:10]([N:11]=2)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 107745254-chloroimidazo[1,2-a]quinoxaline

Product 1

HCID 4625284HCID 4625284, compound

Procedure

By reaction of 4-chloroimidazo[1,2-a]quinoxaline (example 1) with piperidine, according to a procedure that is similar to that followed in example 3, there is obtained 4-(1-piperidinyl)imidazo[1,2-a]quinoxaline. m.p. (DSC)=108.2° C.(onset); IR (KBr): 3107, 2935, 1517 cm-1 ; 1H NMR (CDCl3): δ7.9 (1H,d, J=2 Hz), 7.75÷7.4 (3H,m), 7.4÷7.1 (2H,m), 4.3 (4H,t), 1.9÷1.6 (6H,m), 7.75÷7.4 (3H,m), 7.4÷7.1 (2H,m), 4.3 (4H,t) 1.9÷1.6 (6H,m); UV (EtOH): λmax =231, 249, 293, 305, 333 nm. Elementary analysis for C15H16N4 (m.w.252.32): calcd. C 71.40, H 6.39, N 22.20%; found C 71.38, H 6.63, N 22.61%.

Sources & evidence

ORD record
ord-5c977c0f95104b32b8587632fb33e347
Source dataset
uspto-grants-2000_09
Patent number
US06124287

Reaction notes

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