Piperidine → HCID 10683188, compound

HRID 1954713Notes

Reaction equation

HRID 1954713 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[CH:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH3:15][C:12]1[N:4]2[C:5]3[C:10]([N:11]=[C:2]([N:16]4[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]4)[C:3]2=[N:14][CH:13]=1)=[CH:9][CH:8]=[CH:7][CH:6]=3

Participants

3

Reactant 2

HCID 8082PiperidineHCID 10488983HCID 10488983, compound

Product 1

HCID 10683188HCID 10683188, compound

Procedure

By reaction of 4-chloro-1-methylimidazo[1,2-a]quinoxaline (example 2) with piperidine, according to a procedure that is similar to that followed in example 3, there is obtained 1-methyl-4-piperidinylimidazo[1,2-a]quinoxaline. m.p. (DSC)=78.9° C. (onset); IR (KBr): 3018, 2927, 1502 cm-1 ; 1H-NMR (CDCl3): δ8.05 (1H,dd), 7.65 (1H,dd), 7.5÷7.0 (3H,m), 4.25 (4H,t), 2.85 (3H,s), 1.9÷1.6 (6H,m); UV (EtOH): λmax =249, 281, 297, 310, 329 nm. Elementary analysis for C14H18N4 (m.w.266.35): calcd. C 72.15, H 6.81, N 21.03%; found C 71.84, H 7.09, N 20.70%.

Sources & evidence

ORD record
ord-38aeb8ca342a4401b22587fde35c32dc
Source dataset
uspto-grants-2000_09
Patent number
US06124287

Reaction notes

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