1-Methylpiperazine → HCID 10468939, compound

HRID 1954716Notes

Reaction equation

Cl[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[CH:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[CH3:15][C:12]1[N:4]2[C:5]3[C:10]([N:11]=[C:2]([N:20]4[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]4)[C:3]2=[N:14][CH:13]=1)=[CH:9][CH:8]=[CH:7][CH:6]=3

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 10488983HCID 10488983, compound

Product 1

HCID 10468939HCID 10468939, compound

Procedure

By reaction of 4-chloro-1-methylimidazo[1,2-a]quinoxaline (example 2) with N-methylpiperazine, according to a procedure that is similar to that followed in example 3, there is obtained 1-methyl-4(N'-methylpiperazinyl)imidazo[1,2-a]quinoxaline. m.p. (DSC)=108.0° C.(onset); IR (KBr): 2928, 1535, 1510 cm-1 ; 1H-NMR (CDCl3): δ8.1 (1H,dd), 7.7 (1H,dd), 7.4÷7.0 (3H,m), 4.35 (4H,t), 2.85 (3H,s), 2.6 (4H,t), 2.3 (3H,s); UV (EtOH): λmax =228, 248, 279, 309, 325 nm. Elementary analysis for C16H19N5 (m.w. 281.36): calcd. C 68.30, H 6.81, N 24.89%; found C 68.37, H 7.15, N 25.05%.

Sources & evidence

ORD record: ord-6df72f744eda4ba6a5fa7ad882873480
Source dataset: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06124287

Reaction notes

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