Cyclohexylamine → HCID 10731766, compound

HRID 1954724Notes

Reaction equation

HRID 1954724 reaction equation
Cl[C:2]1[C:3]2[N:4]([CH:13]=[CH:14][N:15]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[C:7]([F:12])[CH:6]=2.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([NH:22][C:2]2[C:3]3[N:4]([CH:13]=[CH:14][N:15]=3)[C:5]3[C:10]([N:11]=2)=[CH:9][CH:8]=[C:7]([F:12])[CH:6]=3)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 53759589HCID 53759589, compound

Product 1

HCID 10731766HCID 10731766, compound

Procedure

By reacting 4-chloro-8-fluoroimidazo[1,2-a] quinoxaline (example 25) with cyclohexylamine, following a procedure that is similar to that described in example 3, there is obtained 4-cyclohexylamino-8-fluoroimidazo[1,2-a]quinoxalin. m.p. (DSC)=157.6° C.(onset); IR (KBr): 3415, 2927, 1556 cm-1 ; 1H-NMR (CDCl3): δ7.8 (1H,dd, J=2 Hz), 7.7÷7.35 (1H,dd, JHF =16 Hz), 7.55 (1H,d, J=2 Hz), 7.55÷7.25 (1H,dd, JHF =16 Hz), 7.05 (1H,dd), 6.0 (1H,d), 4.25 (1H,m), 2.35÷1.2 (10H,m); UV (EtOH): λmax =226, 239, 285, 297, 323, 337 nm. Elementary analysis for C16H17FN4 (m.w. 284.33): calcd. C 67.59, H 6.03, N 19.71%; found C 67.31, H 6.04, N 19.70%.

Sources & evidence

ORD record
ord-612e0497fa864999b98fd246bd99d694
Source dataset
uspto-grants-2000_09
Patent number
US06124287

Reaction notes

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