HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1954770Generated: October 25, 2026
Acetic Anhydride → 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea
https://huagongshe.com/reaction/1954770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 1-Benzyl-3-(3-chlorophenyl)urea | HCID 581390 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea | HCID 2822854 | — |
Reaction Steps
A mixture of 1-benzyl-3-(3-chlorophenyl)urea (44.78 g) and cyanoacetic acid (16.11 g) was ground together and then acetic anhydride (48 ml) added. The resulting mixture was heated and stirred at 75-80° C. for 16 h. It was then allowed to cool, diluted with ether and the product filtered off and washed with ether. This was then recrystallised from toluene with a hot filtration. Yield=20.15 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06124288 |
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| Source dataset | uspto-grants-2000_09 |
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| ORD ID | ord-38c8fe5c3deb44088bfc83b69a904f36 |
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| Source note | uspto-grants-2000_09 |
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