反应详情

温度

77.5 °C

A mixture of 1-benzyl-3-(3-chlorophenyl)urea (44.78 g) and cyanoacetic acid (16.11 g) was ground together and then acetic anhydride (48 ml) added. The resulting mixture was heated and stirred at 75-80° C. for 16 h. It was then allowed to cool, diluted with ether and the product filtered off and washed with ether. This was then recrystallised from toluene with a hot filtration. Yield=20.15 g.

1. temperatureThe resulting mixture was heated
2. temperatureto cool
3. filtrationthe product filtered off
4. washwashed with ether
5. customThis was then recrystallised from toluene with a hot filtration