Triethylamine → HCID 2822834, compound

HRID 1954772Notes

Reaction equation

HRID 1954772 reaction equation
[CH2:1]([N:8]([C:22](=[O:26])[CH2:23][C:24]#[N:25])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([O:20][CH3:21])=[O:19])[CH:13]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C>ClCCl>[NH2:25][C:24]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([O:20][CH3:21])=[O:19])[CH:13]=2)[C:9](=[O:10])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:22](=[O:26])[CH:23]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 23293703HCID 23293703, compound

Product 1

HCID 2822834HCID 2822834, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-Benzyl-1-(cyanoacetyl)-3-[3-(methoxycarbonyl)phenyl]urea (3.51 g) was dissolved in dichloromethane (50 ml) and triethylamine (1.52 g) added. The mixture was stirred for one hour at room temperature and the product filtered off and washed with dichloromethane. Yield=3.16 g.

Workup

  1. filtrationthe product filtered off
  2. washwashed with dichloromethane

Sources & evidence

ORD record
ord-3182106635994fd9be98b11e017102be
Source dataset
uspto-grants-2000_09
Patent number
US06124288

Reaction notes

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