HCID 15548995, compound → HCID 15548996, compound

HRID 1954838Notes

Reaction equation

HRID 1954838 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:29]([CH3:32])([CH3:31])[OH:30])[CH:5]=[C:6]([O:27][CH3:28])[C:7]=1[O:8][C:9]1[C:14]([N+:15]([O-])=O)=[C:13]([NH:18][CH:19]([CH2:23][CH2:24][CH3:25])[CH2:20][CH2:21][CH3:22])[N:12]=[C:11]([CH3:26])[N:10]=1>C(O)C.[Pt]>[Br:1][C:2]1[CH:3]=[C:4]([C:29]([CH3:32])([CH3:31])[OH:30])[CH:5]=[C:6]([O:27][CH3:28])[C:7]=1[O:8][C:9]1[C:14]([NH2:15])=[C:13]([NH:18][CH:19]([CH2:23][CH2:24][CH3:25])[CH2:20][CH2:21][CH3:22])[N:12]=[C:11]([CH3:26])[N:10]=1

Participants

4

Reactant 1

HCID 15548995HCID 15548995, compound

Product 1

HCID 15548996HCID 15548996, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

Platinum black, (5%,0.25 g) was added to a solution of 3-bromo-5-methoxy-α,α-dimethyl-4-[[2-methyl-5-nitro-6-[(1-propylbutyl)amino]-4-pyrimidinyl]oxy]benzenemethanol (0.80 g) in 50 mL of ethanol. The mixture was hydrogenated at a pressure of 41 psi for 18 hours. The mixture was filtered through celite and the filtrate was stripped under reduced pressure. The residue was taken up in 1 N NaOH and extracted with methylene chloride. The combined methylene chloride extracts were dried over MgSO4 and the filtrate was stripped under reduced pressure to yield the title compound, mp 114-116° C.

Workup

  1. filtrationThe mixture was filtered through celite
  2. extractionextracted with methylene chloride
  3. dry with materialThe combined methylene chloride extracts were dried over MgSO4

Sources & evidence

ORD record
ord-4f08e60c2d1841eca4390dbb3fbfb7f2
Source dataset
uspto-grants-2000_09
Patent number
US06124300

Reaction notes

Loading…