反应详情

A mixture of ethyl 3-(2-fluorophenyl)propionate (25.54 g, 0.130 mol) and a 50% aqueous solution of sodium hydroxide (30 mL) in water (130 mL) was refluxed for 2 h. After cooling the mixture was washed with diethyl ether (2×100 mL). The aqueous phase was chilled in an ice bath, and the pH was adjusted to 3 with hydrochloric acid. The white precipitate which formed was collected by filtration, washed repeatedly with water, and dried in a vacuum at 60° C. for 18 h to give 18.66 g (85%) of 3-(2-fluorophenyl)prionic acid as a white solid; m.p., 72-74° C. This material was used without further purification.

1. temperatureAfter cooling the mixture
2. washwas washed with diethyl ether (2×100 mL)
3. temperatureThe aqueous phase was chilled in an ice bath
4. customThe white precipitate which formed
5. filtrationwas collected by filtration
6. washwashed repeatedly with water
7. customdried in a vacuum at 60° C. for 18 h
8. customto give 18.66 g (85%) of 3-(2-fluorophenyl)prionic acid as a white solid
9. customm.p., 72-74° C
10. customThis material was used without further purification