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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1954881Generated: November 2, 2026

(E)-2-(6-fluoro-1-indanylidene)acetamide → (E)-2-(5-fluoro-1-indanylidene)acetamide

https://huagongshe.com/reaction/1954881

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-2-(6-fluoro-1-indanylidene)acetamideHCID 9837001—
Reactant(E)-2-(6-fluoro-1-indanylidene)acetyl chlorideHCID 15491026—
Product(E)-2-(5-fluoro-1-indanylidene)acetamideHCID 1095436644%

Reaction Steps

This compound was prepared in a similar manner to that described for (E)-2-(6-fluoro-1-indanylidene)acetamide Example 1k by substituting (E)-2-(5-fluoro-1-indanylidene)acetyl chloride (3.16 g, 0.015 mol) for (E)-2-(6-fluoro-1-indanylidene)acetyl chloride. Recrystallization from acetonitrile:water mixtures gave 1.28 g (44%) of (E)-2-(5-fluoro-1-indanylidene)acetamide as a white solid; m.p., 191-193° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06124284
Source datasetuspto-grants-2000_09
ORD IDord-6cc132322e324f6b98f635415a3acc2b
Source noteuspto-grants-2000_09