Oxalyl chloride → HCID 23293646, compound

HRID 1954915Notes

Reaction equation

HRID 1954915 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]2[C:11]([C:12](=[O:21])[CH2:13][CH:14]2CC(O)=O)=[CH:10][CH:9]=1>ClCCl>[F:7][C:8]1[CH:16]=[C:15]2[C:11]([C:12](=[O:21])[CH2:13][CH:14]2[CH2:1][C:2]([Cl:4])=[O:3])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 23293583HCID 23293583, compound

Product 1

HCID 23293646HCID 23293646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (4.5 g, 0.035 mol, Aldrich) was added to an ice cold stirring mixture of 2-(6-fluoro-3-oxo-1-indanyl)acetic acid (5.0 g, 0.024 mol) in dichloromethane (200 ml) under a nitrogen atmosphere. The mixture was allowed to warm to room temperature and stirring was continued for 48 hrs. The volatiles were removed from the solution by spin evaporation in vacuo with the addition of dichloromethane (3×50 ml) to give 2-(6-fluoro-3-oxo-1-indanyl)acetyl chloride which was used without purification or analysis.

Workup

  1. stirringstirring
  2. customThe volatiles were removed from the solution by spin evaporation in vacuo with the addition of dichloromethane (3×50 ml)

Sources & evidence

ORD record
ord-bbc447a879b4464c9f455e0181a94f8a
Source dataset
uspto-grants-2000_09
Patent number
US06124284

Reaction notes

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