Ethyl nitroacetate → HCID 59896635, compound

HRID 1954994Notes

Reaction equation

HRID 1954994 reaction equation
CS[C:3](=[N:13][CH3:14])[NH:4][CH2:5][C:6]1[CH:7]=[N:8][C:9]([Cl:12])=[CH:10][CH:11]=1.[N+:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])([O-:17])=[O:16]>>[Cl:12][C:9]1[N:8]=[CH:7][C:6]([CH2:5][NH:4][C:3]([NH:13][CH3:14])=[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 69379Ethyl nitroacetateHCID 22450336HCID 22450336, compound

Product 1

HCID 59896635HCID 59896635, compoundYield 57.3%

Conditions

Temperature
77.5 °C

Procedure

A mixture of 1.4 g (0.0061 mole) of S-methyl-N-(6-chloro-3-pyridylmethyl)-N'-methylisothiourea obtained in Example 64 (2) and 2.7 g of ethyl nitroacetate was stirred with heating at 75-80° C. for 3 hours. After cooling, the crystals were collected by filtration, washed with CH3CN and dried. The procedure gave 1.1 g of the title compound as white crystals.

Workup

  1. temperatureAfter cooling
  2. filtrationthe crystals were collected by filtration
  3. washwashed with CH3CN
  4. customdried

Sources & evidence

ORD record
ord-a921c96a180f4c6894a49e86ed7d0073
Source dataset
uspto-grants-2000_09
Patent number
US06124297

Reaction notes

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