2-Chloroethyl chloroformate → HCID 23294174, compound

HRID 1954998Notes

Reaction equation

HRID 1954998 reaction equation
[NH2:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([Cl:16])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.Cl[C:23]([O:25][CH2:26][CH2:27][Cl:28])=[O:24]>ClCCl>[Cl:28][CH2:27][CH2:26][O:25][C:23]([NH:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([Cl:16])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1)=[O:24]

Participants

4

Reactant 2

HCID 123052-Chloroethyl chloroformateHCID 15388763HCID 15388763, compound

Product 1

HCID 23294174HCID 23294174, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to the procedure indicated in Example 1a, 8-(2-amino-6-methylbenzylamino)-3-chloro-2-methylimidazo[1,2-a]pyridine (0.27 g) and 2-chloroethyl chloroformate (0.18 g) in dichloromethane (30 ml) give the title compound as a brown oil, which is used directly for further reaction in 2b.

Sources & evidence

ORD record
ord-e06463c5b7f941ebbfb8d1dad48d1911
Source dataset
uspto-grants-2000_09
Patent number
US06124313

Reaction notes

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