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HRID1955009

反应详情

EQUATION

反应方程式

HRID 1955009 的结构方程式

REACTANTS

反应物

4
结构：[I-].[Na+]
HCID5238

Sodium Iodide

INa

结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：Cc1cccc(NC(=O)OC(C)(C)C)c1CCl
HCID14368482

未命名化合物

结构：Cc1nc2c(N)cccn2c1C=O
HCID21873989

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc(NC(=O)OC(C)(C)C)c1CNc1cccn2c(C=O)c(C)nc12
HCID23294184

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Starting from 8-amino-3-formyl-2-methylimidazo[1,2-a]pyridine (4.0 g), 2-tert-butoxycarbonylamino-6-methylbenzyl chloride (7.0 g), sodium iodide (4.1 g) and sodium carbonate (6.1 g) in acetone (250 ml) analogously using the process of Example B1 gives, after chromatography on silica gel (eluent toluene/dioxane 9:1) and recrystallization from diisopropyl ether, 7.3 g (81%) of the title compound of m.p. 210-212° C.

WORKUP

后处理

  1. customgives
  2. customafter chromatography on silica gel (eluent toluene/dioxane 9:1) and recrystallization from diisopropyl ether, 7.3 g (81%) of the title compound of m.p. 210-212° C.