Methanol → HCID 178498455, compound

HRID 1955118Notes

Reaction equation

HRID 1955118 reaction equation
[C:1]([Cl:4])(=[O:3])C.[NH:5]1[CH:9]=[C:8](C(O)=O)[CH:7]=[N:6]1.[CH3:13][OH:14]>>[ClH:4].[NH:6]1[CH:7]=[CH:8][C:9]([C:13]([O:3][CH3:1])=[O:14])=[N:5]1

Participants

4

Reactant 3

HCID 887MethanolHCID 6367Acetyl chlorideHCID 3015937Pyrazole-4-carboxylic acid

Product 1

HCID 178498455HCID 178498455, compoundYield 90%

Procedure

10 mL of methanol at 0° C. was treated dropwise with lmL acetyl chloride, followed by addition of 2.0 g(17.84 mmol) of 4-pyrazolcarboxylic acid, followed by warming the mixture at reflux for 18 h. The solution was cooled and concentrated in vacuo to afford 2.6 g(90%) of the title compound as a white solid. 1H NMR (CD3OD) δ8.25, 3.86.

Workup

  1. temperatureby warming the mixture
  2. temperatureat reflux for 18 h
  3. temperatureThe solution was cooled
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-872b31d9a7b542ba8f669274112e8122
Source dataset
uspto-grants-2000_09
Patent number
US06124334

Reaction notes

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