Ammonia → 1,3,5-Triazine-2,4-diamine, 6-chloro-

In a four-necked flask equipped with a stirrer, a thermometer and a condenser, 184.4 g (1.0 mol) of cyanuric chloride and 800 ml of acetonitrile were dissolved at room temperature, and a system was cooled, followed by adding dropwise 303.7 g (5.0 mol) of 28% aqueous ammonia over 2 hours while vigorously stirring and maintaining reaction temperature at not more than 10° C. After that, stirring was continued for 1 hour after heating to room temperature, followed by gradually heating to 50° C. and further aging for 4 hours. After cooling to room temperature, a product was filtered and washed with a large quantity of an ion-exchanged water, followed by drying in vacuo to obtain 115 g (yield of 79%) of 2,4-bis(amino)-6-chloro-1,3,5-triazine.

1. customIn a four-necked flask equipped with a stirrer
2. temperaturea system was cooled
3. temperaturemaintaining
4. customreaction temperature at not more than 10° C
5. stirringAfter that, stirring
6. temperatureby gradually heating to 50° C.
7. waitfurther aging for 4 hours
8. temperatureAfter cooling to room temperature
9. filtrationa product was filtered
10. washwashed with a large quantity of an ion-exchanged water
11. customby drying in vacuo

ORD record

ord-5e5cf39ed3a24ae784053d18d9949ed7

Source dataset

uspto-grants-2000_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06124381