Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-(4-Methylbenzyl)-1-[2-(4-nitrophenoxy)ethyl]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(2-Bromoethoxy)-4-nitrobenzene | HCID 235987 | — |
| 반응물 | 4-[(4-Methylphenyl)methyl]piperidine | HCID 3375603 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(4-Methylbenzyl)-1-[2-(4-nitrophenoxy)ethyl]piperidine | HCID 23294237 | 100% |
반응 단계
From a mixture of 4-(4-methylbenzyl)piperidine (2.27 g, 12.0 mmol), 2-(4-nitrophenoxy)ethyl bromide (1.42 g, 6.0 mmol), K2CO3 (130 mg) and KI (120 mg) in toluene (25 mL) was obtained 2.02 g (100%) of the title compound as a viscous oil. 1H NMR (CDCl3): 1.25-1.38 (m, 2H), 1.46-1.56 (m, 1H), 1.63-1.67 (m, 2H), 2.01-2.09 (m, 2H), 2.314 (s, 3H), 2.498 (d, 2H), J=7), 2.797 (t, 2H), J=6), 2.94-2.98 (m, 2H), 4.171 (t, 21, J=6), 6.950 (d, 26, J=9), 7.059 (AB, 4H, J=8), 8.191 (d, 2H, J=9). The hydrochloride, mp. 180-1° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06124323 |
| 출처 데이터셋 | uspto-grants-2000_09 |
| ORD ID | ord-c9d8f709370b43f1b1b94e6b6eb8e1e0 |
| 출처 메모 | uspto-grants-2000_09 |