反应详情

From a mixture of 4-(4-methylbenzyl)piperidine (2.27 g, 12.0 mmol), 2-(4-nitrophenoxy)ethyl bromide (1.42 g, 6.0 mmol), K2CO3 (130 mg) and KI (120 mg) in toluene (25 mL) was obtained 2.02 g (100%) of the title compound as a viscous oil. 1H NMR (CDCl3): 1.25-1.38 (m, 2H), 1.46-1.56 (m, 1H), 1.63-1.67 (m, 2H), 2.01-2.09 (m, 2H), 2.314 (s, 3H), 2.498 (d, 2H), J=7), 2.797 (t, 2H), J=6), 2.94-2.98 (m, 2H), 4.171 (t, 21, J=6), 6.950 (d, 26, J=9), 7.059 (AB, 4H, J=8), 8.191 (d, 2H, J=9). The hydrochloride, mp. 180-1° C.