Hydrogen Sulfide → HCID 10948415, compound

HRID 1955300Notes

Reaction equation

HRID 1955300 reaction equation
[C:1]([CH2:3][N:4]1[C:9](=[O:10])[CH:8]=[CH:7][C:6]([C:11]2[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:13][N:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=23)=[N:5]1)#[N:2].C(N(CC)CC)C.[SH2:33].O>N1C=CC=CC=1>[O:10]=[C:9]1[CH:8]=[CH:7][C:6]([C:11]2[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:13][N:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=23)=[N:5][N:4]1[CH2:3][C:1](=[S:33])[NH2:2]

Participants

6

Reactant 4

HCID 402Hydrogen SulfideHCID 962WaterHCID 8471TriethylamineHCID 23295199HCID 23295199, compound

Product 1

HCID 10948415HCID 10948415, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Into a mixture of 3-(2-cyanomethyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridine (2.0 g) and triethylamine (1.02 ml) in pyridine (10 ml) was introduced hydrogen sulfide at 50° C. for 6 hours. The mixture was poured into water. The resulting solid was collected by filtration to give 3-(3-oxo-2-thiocarbamoylmethyl-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridine (2.18 g).

Workup

  1. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-d94b4f48c2b042a0906e8ac930ce6cbf
Source dataset
uspto-grants-2000_09
Patent number
US06124456

Reaction notes

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