Acetic Anhydride → HCID 43131892, compound

HRID 1955446Notes

Reaction equation

HRID 1955446 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].C(OC(=O)C)(=[O:15])C.C[N:21]([C:23]1[CH:28]=[CH:27]C=CN=1)C>C1COCC1>[N:7]1([CH2:27][CH2:28][C:23]([NH2:21])=[O:15])[C:8]2[C:4](=[CH:3][CH:2]=[CH:10][CH:9]=2)[C:5](=[O:12])[C:6]1=[O:11]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 218852-DimethylaminopyridineHCID 2365665-Fluoroisatin

Product 1

HCID 43131892HCID 43131892, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 5-fluoroisatin (III, 0.803 g), acetic anhydride (0.546 g), dimethylaminopyridine (0.0059 g) and THF (25 ml) is stirred at 20°-25° for 1.25 hr. THF is then removed and dichloromethane is added. After standing, the crystals are collected and dried to give 5-fluoroisatin acetamide (IV).

Workup

  1. customTHF is then removed
  2. additiondichloromethane is added
  3. customthe crystals are collected
  4. customdried

Sources & evidence

ORD record
ord-43a41945ca11495fb64239b91a6f1e36
Source dataset
uspto-grants-1998_07
Patent number
USRE035840

Reaction notes

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