1-Isocyanato-4-methoxybenzene → HCID 178492395, compound

HRID 1955588Notes

Reaction equation

HRID 1955588 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=1)[N:6]=[C:5]2[OH:20].[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1>O1CCCC1>[Cl:19][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][C:15]=1[Cl:18])[CH2:11][N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:30]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([O:22][CH3:21])=[CH:24][CH:25]=3)=[O:31])=[CH:10][CH:9]=2)[C:5]([OH:20])=[N:6]1

Participants

4

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 178507258HCID 178507258, compound

Product 1

HCID 178492395HCID 178492395, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.54.g 5-amino-1-(3,4-dichlorobenzyl)-1H-indazole-3-ol and 1.12 g 4-methoxyphenyl isocyanate are stirred in 75 ml tetrahydrofuran for 5 hours at room temperature. the solution is concentrated to one third of its volume under vacuum and the precipitate crystallized out after cooling is filtered off under suction. It is recrystallized from n-butanol.

Workup

  1. concentrationthe solution is concentrated to one third of its volume under vacuum
  2. customthe precipitate crystallized out
  3. temperatureafter cooling
  4. filtrationis filtered off under suction
  5. customIt is recrystallized from n-butanol

Sources & evidence

ORD record
ord-9c966aaff50340519535b33cd5dfb970
Source dataset
uspto-grants-1998_07
Patent number
US05776932

Reaction notes

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