HCID 18624523, compound → HCID 19071327, compound

HRID 1955626Notes

Reaction equation

HRID 1955626 reaction equation
NC1N(CC2CCC2)C(=O)N(CC2CCC2)C(=O)C=1.[NH2:20][C:21]1[N:26]([CH2:27][CH:28]2C[CH2:31][CH2:30][CH2:29]2)[C:25](=[O:33])[N:24]([CH2:34][CH:35]2[CH2:39][CH2:38][CH2:37]C2)[C:23](=[O:40])[C:22]=1[N:41]=[O:42]>>[NH2:20][C:21]1[N:26]([CH2:27][CH:28]2[CH2:31][CH2:30][CH2:29]2)[C:25](=[O:33])[N:24]([CH2:34][CH:35]2[CH2:39][CH2:38][CH2:37]2)[C:23](=[O:40])[C:22]=1[N:41]=[O:42]

Participants

3

Reactant 2

HCID 18624523HCID 18624523, compoundHCID 19071295HCID 19071295, compound

Product 1

HCID 19071327HCID 19071327, compound

Procedure

In the manner of step (c) of Example 1, 6-amino-1,3-bis(cyclobutylmethyl)uracil (from step (b), 5.75 g, 21.8 mmol) was converted to 6-amino-1,3-bis(cyclopentylmethyl)-5-nitrosouracil, isolated as purple flakes (5.60 g, 88%), m.p. 251°-252° C.; 1H-NMR (DMSO-d6) consistent with structure.

Workup

  1. customisolated as purple flakes (5.60 g, 88%), m.p. 251°-252° C.

Sources & evidence

ORD record
ord-3aea464f54bf4a35bd91cf53ad13cbc1
Source dataset
uspto-grants-1998_07
Patent number
US05776940

Reaction notes

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