反应详情

3.3 g (9.5 mmol) of methyl 2-[4-(2-butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)-phenyl]-acetate are dissolved in 100 ml of dioxane/water (1:1) at 0° C. and a solution of 0.44 g (10.4 mmol) of lithium hydroxide monohydrate in 5 ml of water is added dropwise with stirring. After stirring at room temperature for 3 h, the mixture is concentrated to a half, diluted with water, washed with diethyl ether, and the aqueous phase is acidified with 1N hydrochloric acid and extracted three times with ethyl acetate. The combined ethyl acetate phases are dried over sodium sulphate and concentrated.

1. stirringAfter stirring at room temperature for 3 h
2. concentrationthe mixture is concentrated to a half
3. additiondiluted with water
4. washwashed with diethyl ether
5. extractionextracted three times with ethyl acetate
6. dry with materialThe combined ethyl acetate phases are dried over sodium sulphate
7. concentrationconcentrated