HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1955742Generated: November 1, 2026
Hydrochloric Acid → tert-Butyl 2-[4-(2-butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetate
https://huagongshe.com/reaction/1955742
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | tert-Butyl 2-[4-(2-butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetate | HCID 15225591 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl 2-[4-(2-butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetate | HCID 19072492 | — |
Reaction Steps
265 mg (7 mmol) of sodium borohydride are added to 3.2 g (7 mmol) of the compound from Example I in 30 ml of EtOH and the mixture is stirred at 25° C. for 1 h. After addition of dilute HCl (pH 6), the mixture is extracted three times with CH2Cl2, the organic phase is dried over Na2SO4 and concentrated, and the residue is chromatographed on silica gel 60 using petroleum ether/ethyl acetate (1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05776964 |
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| Source dataset | uspto-grants-1998_07 |
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| ORD ID | ord-5ba033133f494f9a902baaa217621160 |
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| Source note | uspto-grants-1998_07 |
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