反应详情

温度

25 °C

265 mg (7 mmol) of sodium borohydride are added to 3.2 g (7 mmol) of the compound from Example I in 30 ml of EtOH and the mixture is stirred at 25° C. for 1 h. After addition of dilute HCl (pH 6), the mixture is extracted three times with CH2Cl2, the organic phase is dried over Na2SO4 and concentrated, and the residue is chromatographed on silica gel 60 using petroleum ether/ethyl acetate (1:1).

1. extractionthe mixture is extracted three times with CH2Cl2
2. dry with materialthe organic phase is dried over Na2SO4
3. concentrationconcentrated
4. customthe residue is chromatographed on silica gel 60 using petroleum ether/ethyl acetate (1:1)