HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Benzodioxol-5-amine → 2-(4-Methoxyphenyl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Benzodioxol-5-amine | HCID 84310 | — |
| Reactant | (S)-alpha-[N-[(1,1-Dimethylethyl)carbonyl]amino]-4-methoxy-alpha-methylbenzeneacetic acid | HCID 69968462 | — |
| Product | 2-(4-Methoxyphenyl)propionamide | HCID 20269889 | — |
Reaction Steps
(S)-α-[N-[(1,1-Dimethylethyl)carbonyl]amino]-4-methoxy-α-methylbenzeneacetic acid (preparation described in step A of Example 101) was condensed with 3,4-(methylenedioxy)aniline following the procedure described in step A of Example 99. Pure (S)-N-(1,3-benzodioxol-5-yl)-α-[N-[(1,1-dimethylethyl)carbonyl]]amino!-4-methoxy-α-methyl-benzeneacetamide, obtained after chromatography on silica gel using 30% EtOAc/hexane as eluant, was converted to the title compound following the procedure described in step A of Example 98.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05776983 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-7510149ed192430ea0ba7657102135c4 |
| Source note | uspto-grants-1998_07 |