2,4-Dinitrophenol → 4-tert-Butyl-2,6-dinitroanisole

Participants

Reaction Steps

This product was then subjected to hydrolytic separation of the 2,4-dinitrophenol in accordance with the procedure described in Example 6 to afford 6.18 g (98.9% yield) that corresponds to 33.6% of total yield of the 2,4-dinitrophenol separated and 19.37 g 2,6-dinitro-4-tertbutylanisole (95.2% yield, calculated on the theoretical yield possible) contaminated with 3.88 g of the 2-nitro-4-tertbutylanisole. Subsequent crystallization from methyl alcohol (20 ml, cooled -5° C.) afforded 14.72 g of 99.4% pure 2,6-dinitro-4-tertbutylanisole with 57.5% total yield.

Provenance & Evidence