反应详情

In a reactor equipped with a stirrer and a thermometer, (-)-5-decyloxy-2-[4-(6-hydroxyheptynyl)phenyl]pyrimidine (4.0 g), 5% Pd/C (0.5 g) and THF (50 ml) are charged, and the mixture is reacted at room temperature for 17 hours in a hydrogen atmosphere under ordinary pressure. After filtrating the catalyst off, the reaction mixture is evaporated under reduced pressure. A resulting residue is purified by silica gel column chromatography (eluent: toluene-ethyl acetate) to obtain (-)-5-decyloxy-2-[4-(6-hydroxyheptyl)phenyl]pyrimidine (4.11 g). [α]D =-2.8° (c=1.055, CHCl3).

1. customIn a reactor equipped with a stirrer
2. filtrationAfter filtrating the catalyst off, the reaction mixture
3. customis evaporated under reduced pressure
4. customA resulting residue is purified by silica gel column chromatography (eluent: toluene-ethyl acetate)