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Piperazine → 1-[6-(1-Propyloxy)indan-1-yl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 6-(1-Propoxy)indan-1-one | HCID 22375391 | — |
| 触媒 | Titanium isopropoxide | HCID 11026 | — |
| 生成物 | 1-[6-(1-Propyloxy)indan-1-yl]piperazine | HCID 22375388 | — |
反応手順
Piperazine (20.6 g, 0.24 mol), 6-(1-propoxy)indan-1-one (4.6 g, 24 mmol), titanium(IV) isopropoxide (16 ml, 48 mmol) and sodium borohydride (2.8 g, 74 mmol) were reacted by Method A to give the product which was converted to the fumarate salt (beige solid, 5.0 g, 55.4%, mp: 157°-159° C.). Calcd for C16H24N2O.C4H4O4.0.3H2O: C, 62.91%; H, 7.55%; N, 7.34%. Found: C, 62.70%; H, 7.45%; N, 7.07%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05780470 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-bf31a163591c4620929cf32375c5b731 |
| 出典メモ | uspto-grants-1998_07 |