反应详情

Piperazine (20.6 g, 0.24 mol), 6-(1-propoxy)indan-1-one (4.6 g, 24 mmol), titanium(IV) isopropoxide (16 ml, 48 mmol) and sodium borohydride (2.8 g, 74 mmol) were reacted by Method A to give the product which was converted to the fumarate salt (beige solid, 5.0 g, 55.4%, mp: 157°-159° C.). Calcd for C16H24N2O.C4H4O4.0.3H2O: C, 62.91%; H, 7.55%; N, 7.34%. Found: C, 62.70%; H, 7.45%; N, 7.07%.

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