HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxaldehyde → HCID 22375401, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one | HCID 13059023 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Product | HCID 22375401 | HCID 22375401 | 88% |
Reaction Steps
1-Formyl-piperazine (2.1 g, 20 mmol), 5-fluoro-6-methoxy-indan-1-one (1.8 g, 10 mmol), titanium(IV) isopropoxide (5 ml, 15 mmol), and sodium borohydride (1.2 g, 30 mmol) were reacted by Method B to give the product (2.2 g, 88%, mp 163°-166° C.). Calcd for C14H19 FN2O.C4H4O4.0.1H2O: C, 56.23%; H, 6.56%; N, 7.28%. Found: C, 56.65%; H, 6.41%; N, 6.98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780470 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-91d8006efb1747a18512441d98a28462 |
| Source note | uspto-grants-1998_07 |