1-Piperazinecarboxaldehyde → HCID 22375401, compound

HRID 1956149Notes

Reaction equation

HRID 1956149 reaction equation
[CH:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=O.[F:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][C:18]=1[O:19][CH3:20])C(=O)[CH2:14][CH2:13]2.[BH4-].[Na+]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[F:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][C:18]=1[O:19][CH3:20])[CH:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH2:14][CH2:13]2

Participants

5

Reactant 3

HCID 821911-PiperazinecarboxaldehydeHCID 4311764Sodium borohydrideHCID 130590235-Fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one

Product 1

HCID 22375401HCID 22375401, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideCatalyst

Procedure

1-Formyl-piperazine (2.1 g, 20 mmol), 5-fluoro-6-methoxy-indan-1-one (1.8 g, 10 mmol), titanium(IV) isopropoxide (5 ml, 15 mmol), and sodium borohydride (1.2 g, 30 mmol) were reacted by Method B to give the product (2.2 g, 88%, mp 163°-166° C.). Calcd for C14H19 FN2O.C4H4O4.0.1H2O: C, 56.23%; H, 6.56%; N, 7.28%. Found: C, 56.65%; H, 6.41%; N, 6.98%.

Sources & evidence

ORD record
ord-91d8006efb1747a18512441d98a28462
Source dataset
uspto-grants-1998_07
Patent number
US05780470

Reaction notes

Loading…