反应详情

温度

0 °C

1-Amino-6-(2-morpholine-4-yl-ethoxy)-3-phenyl-1H-indene-2-carboxylic acid cyclohexylamide (14 mg, 0.03 mmol) prepared in Example 22 was dissolved in dichloromethane (10 mL), acetyl chloride (24 mg, 0.3 mmol) and triethylamine (30 mg, 0.3 mmol) were added thereto in order at 0° C., and stirred for 24 hrs at RT. The resulting mixture washed with saturated saline and extracted with dichloromethane. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 3 mg of the titled compound (yield: 20%).

1. washThe resulting mixture washed with saturated saline
2. extractionextracted with dichloromethane
3. customThe organic layer was separated
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated under a reduced pressure
6. customThe resulting residue was purified by flash chromatography