Diethyl (ethoxymethylene)malonate → HCID 23209189, compound

HRID 1956411Notes

Reaction equation

HRID 1956411 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH3:9])=[N:6][CH:7]=1.C(O[CH:13]=[C:14]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:15]([O:17][CH2:18][CH3:19])=[O:16])C>>[CH2:8]([C:5]1[N:6]=[CH:7][C:2]([NH:1][CH:13]=[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:3][CH:4]=1)[CH3:9]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 138607296-Ethylpyridin-3-amine

Product 1

HCID 23209189HCID 23209189, compound

Procedure

A mixture of 5-amino-2-ethylpyridine (17.6 g) and diethyl ethoxymethylenemalonate (23.25 g) was heated on a steam bath for 2.5 hours. The mixture was cooled in ice. The solid formed was ground up in petroleum ether, b.p. 60°-80° C. and then filtered to give diethyl 2-(6-ethyl-3-pyridylaminomethylene)malonate, m.p. 55°-57° C.

Workup

  1. temperaturewas heated on a steam bath for 2.5 hours
  2. temperatureThe mixture was cooled in ice
  3. customThe solid formed
  4. filtrationb.p. 60°-80° C. and then filtered

Sources & evidence

ORD record
ord-90642106827f47e9a9fd2b954fa13ce2
Source dataset
uspto-grants-1998_07
Patent number
US05780482

Reaction notes

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