Phosphorus oxychloride → HCID 23209286, compound

HRID 1956417Notes

Reaction equation

O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=2)[N:5]=[CH:4][C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=2)[N:5]=[CH:4][C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178469584HCID 178469584, compound

Product 1

HCID 23209286HCID 23209286, compound

Conditions

Temperature: 50 °C

Procedure

A mixture of ethyl 4-hydroxy-6-phenoxy-1,5-naphthyridine-3-carboxylate (3.0 g) and phosphorus oxychloride (25 ml) was heated at 50° C. for 1 hour and then worked up as described in Example B1 to give ethyl 4-chloro-6-phenoxy-1,5-naphthyridine-3-carboxylate, m.p. 133°-137° C.

Sources & evidence

ORD record: ord-7997e8bf8b5646f78b64606889d20d95
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05780482

Reaction notes

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