Phosphorus oxychloride → HCID 23209231, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-ethoxy-8-hydroxypyrido[2,3-b]pyrazine-7-carboxylate (2.5 g) was added to a stirred solution of phosphorus oxychloride (50 ml) with stirring. The mixture was heated at 50° C. for 3 hours and then worked up as described in Example B1 to give ethyl 8-chloro-3-ethoxypyrido[2,3-b]pyrazine-7-carboxylate which was used directly.

Provenance & Evidence