Phosphorus oxychloride → HCID 23209231, compound

HRID 1956419Notes

Reaction equation

[CH2:1]([O:3][C:4]1[N:9]=[C:8]2[N:10]=[CH:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13](O)[C:7]2=[N:6][CH:5]=1)[CH3:2].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:13]1[C:7]2[C:8](=[N:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][N:6]=2)[N:10]=[CH:11][C:12]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178469696HCID 178469696, compound

Product 1

HCID 23209231HCID 23209231, compound

Conditions

Temperature: 50 °C

Procedure

Ethyl 3-ethoxy-8-hydroxypyrido[2,3-b]pyrazine-7-carboxylate (2.5 g) was added to a stirred solution of phosphorus oxychloride (50 ml) with stirring. The mixture was heated at 50° C. for 3 hours and then worked up as described in Example B1 to give ethyl 8-chloro-3-ethoxypyrido[2,3-b]pyrazine-7-carboxylate which was used directly.

Sources & evidence

ORD record: ord-2f382417f0c2450d889c96d8fab09a22
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05780482

Reaction notes

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