反应详情

A mixture of 5-chloro-3-ethoxy-2-methyl-1,8-naphthyridine (2.0 g), 5-aminopyridin-2-ol (1.0 g) and IMS (20 ml) was boiled under reflux for 2 hours. The mixture was cooled and filtered to give 5-(3-ethoxy-2-methyl-1,8-naphthyridin-5-ylamino)pyridin-2-ol hydrochloride sesquihydrate, m.p. 295°-300° C.

1. temperatureunder reflux for 2 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered