反应详情

A mixture of 5-chloro-3-ethoxy-2-methyl-1,8-naphthyridine (2.0 g), 5-amino-2-ethoxypyridine (1.25 g) and IMS (20 ml) was boiled under reflux for 2 hours. The mixture was cooled and filtered to give 3-ethoxy-5-(2-ethoxy-5-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride dihydrate, m.p. 184°-187° C. Active (2/3) at 30 mg/kg.

1. temperatureunder reflux for 2 hours
2. temperatureThe mixture was cooled
3. filtrationfiltered