HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Ethoxypyridin-3-amine → 3-Ethoxy-5-(2-ethoxy-5-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride dihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Ethoxypyridin-3-amine | HCID 3040301 | — |
| Reactant | 5-Chloro-3-ethoxy-2-methyl-1,8-naphthyridine | HCID 19374266 | — |
| Product | 3-Ethoxy-5-(2-ethoxy-5-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride dihydrate | HCID 23209212 | — |
Reaction Steps
A mixture of 5-chloro-3-ethoxy-2-methyl-1,8-naphthyridine (2.0 g), 5-amino-2-ethoxypyridine (1.25 g) and IMS (20 ml) was boiled under reflux for 2 hours. The mixture was cooled and filtered to give 3-ethoxy-5-(2-ethoxy-5-pyridylamino)-2-methyl-1,8-naphthyridine hydrochloride dihydrate, m.p. 184°-187° C. Active (2/3) at 30 mg/kg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-4be1b900155c4ca3965c73b4786f8e13 |
| Source note | uspto-grants-1998_07 |