HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Ethoxy-2-pyridinamine → Ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Ethoxy-2-pyridinamine | HCID 586710 | — |
| Reactant | Ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 23198600 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | Ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate | HCID 131720767 | — |
Reaction Steps
A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (1.3 g), 6-amino-2-ethoxy pyridine (0.68 g), IMS (25 ml) and concentrated hydrochloric acid (2 drops) was boiled under reflux for 18 hours. The mixture was cooled and filtered to give ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate, m.p. 195°-200° C. Active (1/1) at 30 mg/kg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05780482 |
| Source dataset | uspto-grants-1998_07 |
| ORD ID | ord-745f2b90cee9427da243b8cfd4480318 |
| Source note | uspto-grants-1998_07 |