HRID1956443

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID586710

6-Ethoxy-2-pyridinamine

C7H10N2O

HCID23198600

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnc2nc(C)c(OCC)cc2c1Nc1cccc(OCC)n1.CCOC(=O)c1cnc2nc(C)c(OCC)cc2c1Nc1cccc(OCC)n1.Cl.Cl.Cl.O.O

HCID131720767

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (1.3 g), 6-amino-2-ethoxy pyridine (0.68 g), IMS (25 ml) and concentrated hydrochloric acid (2 drops) was boiled under reflux for 18 hours. The mixture was cooled and filtered to give ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate, m.p. 195°-200° C. Active (1/1) at 30 mg/kg.

WORKUP

后处理

temperatureunder reflux for 18 hours
temperatureThe mixture was cooled
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-745f2b90cee9427da243b8cfd4480318
来源数据集: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05780482
来源说明: uspto-grants-1998_07

反应 SMILES

[Cl:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([CH3:15])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].[NH2:21][C:22]1[N:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[CH:24][CH:23]=1>Cl>[OH2:12].[ClH:1].[CH2:13]([O:12][C:9]1[CH:10]=[C:11]2[C:6](=[N:7][C:8]=1[CH3:15])[N:5]=[CH:4][C:3]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:2]2[NH:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([O:28][CH2:29][CH3:30])[N:27]=1)[CH3:14].[ClH:1].[ClH:1].[CH2:19]([O:18][C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([O:28][CH2:29][CH3:30])[N:27]=1)=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[C:8]([CH3:15])[N:7]=2)=[O:17])[CH3:20].[OH2:12]