Phenol → HCID 18663603, compound

HRID 1956575Notes

Reaction equation

HRID 1956575 reaction equation
F[C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[C:14]1([OH:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[O:20]([C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 5229292-Fluoro-4-(trifluoromethyl)benzaldehyde

Product 1

HCID 18663603HCID 18663603, compoundYield 78%

Procedure

Preparation analogous to Example 12 from 2-fluoro-4-trifluoromethyl-benzaldehyde and phenol. Yield: 78%, light-coloured crystals, crystallised from hexane; melting point: 57°-59° C.; TLC (silica gel; ethyl acetate/hexane=1:1; UV): Rf =0.71; 1H-NMR (CDCl3, 200 MHz): 7.08-7.50 (m, 7H): 8.05 (d, 1H) 10.60 (s, 1H). MS: 266/265 (M+), 217, 188.

Workup

  1. customYield: 78%, light-coloured crystals, crystallised from hexane

Sources & evidence

ORD record
ord-1b22085b821d409f9305f188870330ab
Source dataset
uspto-grants-1998_07
Patent number
US05780500

Reaction notes

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