3-Chlorophenol → 2-(3-chlorophenoxy)benzaldehyde

HRID 1956603Notes

Reaction equation

HRID 1956603 reaction equation
F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Cl:10][C:11]1[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=1>>[Cl:10][C:11]1[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=1)[O:17][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

3

Reactant 2

HCID 79333-ChlorophenolHCID 67970o-Fluorobenzaldehyde

Product 1

HCID 27634282-(3-chlorophenoxy)benzaldehydeYield 69%

Procedure

Preparation analogous to Example 12a) from 2-fluoro-benzaldehyde and 3-chlorophenol. Yield: 69%; yellow oil after bulb tube distillation (150°-180° C., 0.001 torr); 1H-NMR (CDCl3, 200 MHz): 6.92-7.38 (m, 6H); 7.95 (m, 1H); 10.48 (s, 1H).

Workup

  1. distillationyellow oil after bulb tube distillation (150°-180° C., 0.001 torr)

Sources & evidence

ORD record
ord-8efbeeebfab34d7a94490930d61961e4
Source dataset
uspto-grants-1998_07
Patent number
US05780501

Reaction notes

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