Chlorotrifluoroethylene → 7-Chlorodibenz[b,f]oxepin-10-methanol

HRID 1956604Notes

Reaction equation

HRID 1956604 reaction equation
C(F)(F)=C(Cl)F.[Cl:7][C:8]1[CH:25]=[CH:24][C:11]2[C:12]([C:21](O)=[O:22])=[CH:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[O:16][C:10]=2[CH:9]=1>C(OCC)(=O)C.CCCCCC>[Cl:7][C:8]1[CH:25]=[CH:24][C:11]2[C:12]([CH2:21][OH:22])=[CH:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[O:16][C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 6594ChlorotrifluoroethyleneHCID 18663611HCID 18663611, compound

Product 1

HCID 186636107-Chlorodibenz[b,f]oxepin-10-methanolYield 94%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Preparation analogous to Example 12 f) aus 7-chloro-dibenz[b,f]oxepine-10-carboxylic acid. Yield: 94% in the form of an oil; TLC (silica gel; ethyl acetate/hexane=1:1; UV): Rf =0.38; 1H-NMR (CDCl3, 200 MHz): 1.72 (sbr, 1H); 4.67 (s, 2H); 6.91 (s, 1H); 7.10-7.40 (m, 7H) ; MS: 260/258 (M+), 217/215.

Sources & evidence

ORD record
ord-68deb7c32c1144f2a765b5648b7690d1
Source dataset
uspto-grants-1998_07
Patent number
US05780501

Reaction notes

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