反应详情

Tetrahydrofuran (15 mL), 3,4-dibutoxy-3-cyclobutene-1,2-dione (2.26 g, 10 mmol) and 2-amino-3,3-dimethylbutane (1.01 g, 10 mmol) were stirred together for approximately 65 hours at room temperature. The waxy solid remaining after removal of solvent was dissolved in chloroform (15 mL) and chromatographed (flash, ethyl acetate/hexane) on silica. The appropriate fractions were freed of solvent to yield 2.41 g (95%) of cream-colored waxy solid: mp 90°-9° C.° (softens 85° C.).

1. customafter removal of solvent
2. dissolutionwas dissolved in chloroform (15 mL)
3. customchromatographed (flash, ethyl acetate/hexane) on silica
4. customto yield 2.41 g (95%) of cream-colored waxy solid
5. custommp 90°-9° C.° (softens 85° C.)