反应详情

温度

100 °C

In 100 ml of dimethylformamide was dissolved 4.4 g (0.0115 mol) of crude 1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine and 4.5 g (0.069 mol) of sodium azide was added. The mixture was heated at 100° C. for 2.5 h. It was then poured into water and extracted with ethyl acetate three times. The combined organic phase was washed with water, dried (Na2SO4) and evaporated. The residue was flash chromatographed on silica gel using ethyl acetate/heptane 1/1 as eluent. Yield: 3.0 g (79%).

1. additionwas added
2. extractionextracted with ethyl acetate three times
3. washThe combined organic phase was washed with water
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customchromatographed on silica gel