4-Methylbenzoyl Chloride → HCID 22951202, compound

HRID 1956808Notes

Reaction equation

HRID 1956808 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[C:25]([O:28][CH3:29])[CH:26]=[CH:27][C:21]=3[CH:20]=2)=[CH:15][CH:14]=1.[Al+3].[Cl-].[Cl-].[Cl-]>>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[S:23][C:22]3[CH:24]=[C:25]([O:28][CH3:29])[CH:26]=[CH:27][C:21]=3[C:20]=2[C:6]([C:5]2[CH:9]=[CH:10][C:2]([CH3:1])=[CH:3][CH:4]=2)=[O:7])=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 134054-Methylbenzoyl ChlorideHCID 8509416-Methoxy-2-(4-methoxyphenyl)benzo[b]thiopheneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 22951202HCID 22951202, compoundYield 66.1%

Procedure

In a manner similar to that used in Preparation 3, 2.32 g (15 mmol) of 4-methylbenzoyl chloride, 2 g (7.4 mmol) of 2-(4-methoxyphenyl)-6-methoxybenzo[b]thiophene, and 5.3 g (40 mmol) of AlCl3 were converted to 1.9 g of the title compound, crystallized from Et2O and isolated as a light yellow powder.

Sources & evidence

ORD record
ord-64847e78610948d5846852fef1372b26
Source dataset
uspto-grants-1998_07
Patent number
US05780648

Reaction notes

Loading…